I have been playing guitar for about 10 years now, and until today, I never bothered to set the inonation of any of my guitars. My main guitar is a lefty Steinberger GU Deluxe (http://musicyo.com). I discovered Steinberger guitars around 1999, and I ordered a black GU Deluxe. I didn't play it that much because it was a right handed guitar, but I loved it's headless tuning system. I gave the guitar to my brother a few years ago.

I've been playing the lefty Steinberger for about 2 1/2 years. The EMG select pickups are very quiet, and work well with my Boss GT-6 effects pedal. The guitar stays in tune better than everything else I've tried. Today I set the intonation on it for the first time, which is strange. I always knew that I could move the saddles on my R-trem bridge, but I didn't know the procedure.

This site is a pretty useful guide for adjusting things on a Steinberger.

http://www.musicyo.com/planet/steinberger.asp

I just had to adjust the saddles so that the 24th fret is exactly 2 octaves above each open string. The guitar comes with a mini hex wrench to move the saddles. I found that after I moved a saddle, I have to get in tune again. I tune my guitar with the tuner in my GT-6. After I adjusted the inontation for each string, the guitar sounded much better, especially since the strings are getting old.

I also read about adjusting the truss rod. I loosened it slightly, and the neck made some creaking noises.

Maybe I will even adjust the action height sometime.